KMID : 0881720110260010012
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Journal of Food Hygiene and Safety 2011 Volume.26 No. 1 p.12 ~ p.15
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Analysis of coenzyme Q10 in dietary supplement by HPLC
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No Ki-Mi
Leem Dong-Gil Kim Mi-Gyeong Park Kyoung-Sik Yoon Tae-Hyung Hong-Jin Park Sun-Young Jeong Ja-Young
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Abstract
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A method based on high-performance liquid chromatography (HPLC) with ultraviolet detection has been developed to quantify coenzyme Q10 (CoQ10) in raw materials and dietary supplements. Single-laboratory validation has been performed on the method to determine linearity, selectivity, accuracy, limits of quantification (LOQ) and repeatability for CoQ10. An excellent linearity (r = 0.999) was observed for CoQ10 in the concentration range 15.625~500 ¥ìg/mL in dietary supplement. Observed recovery of CoQ10 was found to be between 98.33 and 99.38%. LOQ was found to be 250 ¥ìg/mL Repeatability precision for CoQ10 was between 0.15 and 0.21% relative standard deviation (RSD). Further, limited studies showed that some adulterants and degraded material could be satisfactorily separated from CoQ10 and identified.
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KEYWORD
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Coenzyme Q10, dietary supplements, HPLC, validation
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